POS0785 CHANGING EXPRESSION PROFILES OF LONG NONCODING RNAS, MIRNAS, MRNAS AND CIRCULAR RNAS IN LABIAL SALIVARY GLANDS OF PRIMARY SJÖGREN’S SYNDROME (PSS)

Background: Primary Sjögren’s syndrome (pSS) is a relatively common autoimmune disease characterized by oral and ocular dryness. An increasing number of studies have revealed that long non-coding RNA (lncRNA), miRNA, mRNA circular (circRNA) contributes to the pathogenesis diseases. Objectives: To explore lncRNA, circRNA expression profiles in labial salivary glands (LSGs) pSS patients their biological functions regulation pSS. Methods: The 75,550 lncRNAs, 2,318 20,292 mRNAs 6,877 circRNAs were determined LSG six healthy controls using microarray experiments. Validation was performed real-time PCR. LncRNA-mRNA co-expression gene-pathway networks constructed bioinformatics software. Results: A total 599 lncRNAs (upregulated: 279, downregulated: 320), 78 miRNAs 26, 52), 615 590, 25) 160 110, 50) differentially expressed LSGs patients. Five these validated lncRNA HCP5, SNHG5, IFI44L, CMPK2 significantly upregulated TTYH1 downregulated GO KEGG pathway analysis predict co-expressed potential targeting genes. Subsequently, ceRNA (lncRNA-miRNA-mRNA) network including 2320 pairs based on predicted shared mRNAs. Conclusion: profile provided systematic perspective miRNAs, Therefore, this study will aid development new diagnostic biomarkers drug therapies. References: [1]Le Dantec C, Varin MM, Brooks WH, Pers JO, Youinou P, Renaudineau Y. Epigenetics Sjogren’s syndrome.Curr Pharm Biotechnol. 2012 Aug;13(10):2046-53. Disclosure Interests: None declared